Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug

ARS-interacting multifunctional proteins 2 (AIMP2) is known to be a powerful tumour suppressor. However, the target AIMP2-DX2, AIMP2-lacking exon 2, is often detected in many cancer patients and cells. The predominant approach for targeting AIMP-DX2 has been attempted via small molecule mediated inh...

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Detalles Bibliográficos
Autores principales: Lee, BoRa, Kim, Dae Gyu, Lee, Aram, Kim, Young Mi, Cui, Lianji, Kim, Sunghoon, Choi, Inhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621298/
https://www.ncbi.nlm.nih.gov/pubmed/36305287
http://dx.doi.org/10.1080/14756366.2022.2135510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621298/
https://www.ncbi.nlm.nih.gov/pubmed/36305287
http://dx.doi.org/10.1080/14756366.2022.2135510

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