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A knowledge graph representation learning approach to predict novel kinase–substrate interactions

The human proteome contains a vast network of interacting kinases and substrates. Even though some kinases have proven to be immensely useful as therapeutic targets, a majority are still understudied. In this work, we present a novel knowledge graph representation learning approach to predict novel...

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Detalles Bibliográficos
Autores principales: Gavali, Sachin, Ross, Karen, Chen, Chuming, Cowart, Julie, Wu, Cathy H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621340/
https://www.ncbi.nlm.nih.gov/pubmed/35975455
http://dx.doi.org/10.1039/d1mo00521a