Imbalance between the function of Na(+)-K(+)-2Cl and K(+)-Cl impairs Cl(–) homeostasis in human focal cortical dysplasia

OBJECTIVE: Altered expression patterns of Na(+)-K(+)-2Cl(–) (NKCC1) and K(+)-Cl(–) (KCC2) co-transporters have been implicated in the pathogenesis of epilepsy. Here, we assessed the effects of imbalanced NKCC1 and KCC2 on γ-aminobutyric acidergic (GABAergic) neurotransmission in certain brain region...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Ru, Xing, Yue, Zhang, Herui, Wang, Junling, Lai, Huanling, Cheng, Lipeng, Li, Donghong, Yu, Tao, Yan, Xiaoming, Xu, Cuiping, Piao, Yueshan, Zeng, Linghui, Loh, Horace H., Zhang, Guojun, Yang, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621392/
https://www.ncbi.nlm.nih.gov/pubmed/36324524
http://dx.doi.org/10.3389/fnmol.2022.954167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621392/
https://www.ncbi.nlm.nih.gov/pubmed/36324524
http://dx.doi.org/10.3389/fnmol.2022.954167

Ejemplares similares