SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice

We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, alt...

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Autores principales: Baz, Mariana, Deshpande, Nikita, Mackenzie-Kludas, Charlie, Mordant, Francesca, Anderson, Danielle, Subbarao, Kanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622237/
https://www.ncbi.nlm.nih.gov/pubmed/36191630
http://dx.doi.org/10.3201/eid2811.220718
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author Baz, Mariana
Deshpande, Nikita
Mackenzie-Kludas, Charlie
Mordant, Francesca
Anderson, Danielle
Subbarao, Kanta
author_facet Baz, Mariana
Deshpande, Nikita
Mackenzie-Kludas, Charlie
Mordant, Francesca
Anderson, Danielle
Subbarao, Kanta
author_sort Baz, Mariana
collection PubMed
description We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection.
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spelling pubmed-96222372022-11-05 SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice Baz, Mariana Deshpande, Nikita Mackenzie-Kludas, Charlie Mordant, Francesca Anderson, Danielle Subbarao, Kanta Emerg Infect Dis Research Letter We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection. Centers for Disease Control and Prevention 2022-11 /pmc/articles/PMC9622237/ /pubmed/36191630 http://dx.doi.org/10.3201/eid2811.220718 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Baz, Mariana
Deshpande, Nikita
Mackenzie-Kludas, Charlie
Mordant, Francesca
Anderson, Danielle
Subbarao, Kanta
SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice
title SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice
title_full SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice
title_fullStr SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice
title_full_unstemmed SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice
title_short SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice
title_sort sars-cov-2 omicron ba.1 challenge after ancestral or delta infection in mice
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622237/
https://www.ncbi.nlm.nih.gov/pubmed/36191630
http://dx.doi.org/10.3201/eid2811.220718
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