Persistent muscle hyperalgesia after adolescent stress is exacerbated by a mild-nociceptive input in adulthood and is associated with microglia activation

Non-specific low back pain (LBP) is a major global disease burden and childhood adversity predisposes to its development. The mechanisms are largely unknown. Here, we investigated if adversity in young rats augments mechanical hyperalgesia and how spinal cord microglia contribute to this. Adolescent...

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Detalles Bibliográficos
Autores principales: Singaravelu, Sathish Kumar, Goitom, Alexander Dawit, Graf, Akseli Petteri, Moerz, Handan, Schilder, Andreas, Hoheisel, Ulrich, Spanagel, Rainer, Treede, Rolf-Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622712/
https://www.ncbi.nlm.nih.gov/pubmed/36316425
http://dx.doi.org/10.1038/s41598-022-21808-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622712/
https://www.ncbi.nlm.nih.gov/pubmed/36316425
http://dx.doi.org/10.1038/s41598-022-21808-x

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