DNAJA1- and conformational mutant p53-dependent inhibition of cancer cell migration by a novel compound identified through a virtual screen

Cancers are frequently addicted to oncogenic missense mutant p53 (mutp53). DNAJA1, a member of heat shock protein 40 (HSP40), also known as J-domain proteins (JDPs), plays a crucial role in the stabilization and oncogenic activity of misfolded or conformational mutp53 by binding to and preventing mu...

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Detalles Bibliográficos
Autores principales: Nishikawa, Shigeto, Kaida, Atsushi, Parrales, Alejandro, Ranjan, Atul, Alalem, Mohamed, Ren, Hongyi, Schoenen, Frank J., Johnson, David K., Iwakuma, Tomoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622836/
https://www.ncbi.nlm.nih.gov/pubmed/36316326
http://dx.doi.org/10.1038/s41420-022-01229-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622836/
https://www.ncbi.nlm.nih.gov/pubmed/36316326
http://dx.doi.org/10.1038/s41420-022-01229-5

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