Characterization of EGFR-reprogrammable temozolomide-resistant cells in a model of glioblastoma

Temozolomide (TMZ) resistance is a major clinical challenge for glioblastoma (GBM). O(6)-methylguanine-DNA methyltransferase (MGMT) mediated DNA damage repair is a key mechanism for TMZ resistance. However, MGMT-null GBM patients remain resistant to TMZ, and the process for resistance evolution is l...

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Detalles Bibliográficos
Autores principales: Gong, Lingli, Yin, Ying, Chen, Cheng, Wan, Quan, Xia, Die, Wang, Mei, Pu, Zhening, Zhang, Bo, Zou, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622861/
https://www.ncbi.nlm.nih.gov/pubmed/36316307
http://dx.doi.org/10.1038/s41420-022-01230-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622861/
https://www.ncbi.nlm.nih.gov/pubmed/36316307
http://dx.doi.org/10.1038/s41420-022-01230-y

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