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Characterization of EGFR-reprogrammable temozolomide-resistant cells in a model of glioblastoma
Temozolomide (TMZ) resistance is a major clinical challenge for glioblastoma (GBM). O(6)-methylguanine-DNA methyltransferase (MGMT) mediated DNA damage repair is a key mechanism for TMZ resistance. However, MGMT-null GBM patients remain resistant to TMZ, and the process for resistance evolution is l...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622861/ https://www.ncbi.nlm.nih.gov/pubmed/36316307 http://dx.doi.org/10.1038/s41420-022-01230-y |