PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer

Protein expression, activation and stability are regulated through inter-connected signal transduction pathways resulting in specific cellular states. This study sought to differentiate between the complex mechanisms of intrinsic and acquired trastuzumab resistance, by quantifying changes in express...

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Detalles Bibliográficos
Autores principales: Scerri, Jeanesse, Scerri, Christian, Schäfer-Ruoff, Felix, Fink, Simon, Templin, Markus, Grech, Godfrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623415/
https://www.ncbi.nlm.nih.gov/pubmed/36329884
http://dx.doi.org/10.3389/fendo.2022.1010092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623415/
https://www.ncbi.nlm.nih.gov/pubmed/36329884
http://dx.doi.org/10.3389/fendo.2022.1010092

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