Cargando…

PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer

Protein expression, activation and stability are regulated through inter-connected signal transduction pathways resulting in specific cellular states. This study sought to differentiate between the complex mechanisms of intrinsic and acquired trastuzumab resistance, by quantifying changes in express...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scerri, Jeanesse, Scerri, Christian, Schäfer-Ruoff, Felix, Fink, Simon, Templin, Markus, Grech, Godfrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623415/ https://www.ncbi.nlm.nih.gov/pubmed/36329884 http://dx.doi.org/10.3389/fendo.2022.1010092

Ejemplares similares

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
por: Baldacchino, Shawn, et al.
Publicado: (2018)

Prevalence and characteristics of community carriage of methicillin-resistant Staphylococcus aureus in Malta
por: Scerri, Jeanesse, et al.
Publicado: (2013)

Copy Number Variations as Determinants of Colorectal Tumor Progression in Liquid Biopsies
por: Debattista, Jessica, et al.
Publicado: (2023)

Targeting HER3 or MEK overcomes acquired Trastuzumab resistance in HER2-positive gastric cancer-derived xenograft
por: Zhang, Mengqi, et al.
Publicado: (2022)

Nanopore Is Preferable over Illumina for 16S Amplicon Sequencing of the Gut Microbiota When Species-Level Taxonomic Classification, Accurate Estimation of Richness, or Focus on Rare Taxa Is Required
por: Szoboszlay, Márton, et al.
Publicado: (2023)

Propranolol, infantile haemangiomas, and serendipity: new use for an old drug
por: Grech, Victor, et al.
Publicado: (2011)

WITHDRAWN: To wear or not to wear? Adherence to face mask use during the COVID-19 and Spanish influenza pandemics
por: Scerri, Mariella, et al.
Publicado: (2020)

WITHDRAWN: COVID-19, its novel vaccination and fake news – What a brew
por: Scerri, Mariella, et al.
Publicado: (2020)

The Spanish flu, COVID-19 and Malta's reactions: Contrasts and similarities
por: Scerri, Mariella, et al.
Publicado: (2020)

Discussion: COVID-19’s impact on sports and athletes
por: Scerri, Mariella, et al.
Publicado: (2021)

O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells
por: Miura, Taichi, et al.
Publicado: (2017)

Psychiatric hospital nurses' attitudes towards trauma‐informed care
por: Cilia Vincenti, Sarah, et al.
Publicado: (2021)

A preclinical evaluation of the MEK inhibitor refametinib in HER2-positive breast cancer cell lines including those with acquired resistance to trastuzumab or lapatinib
por: O’Shea, John, et al.
Publicado: (2017)

Reaching out for Help: Calls to a Mental Health Helpline Prior to and during the COVID-19 Pandemic
por: Scerri, Josianne, et al.
Publicado: (2021)

MEK inhibitors induce Akt activation and drug resistance by suppressing negative feedback ERK‐mediated HER2 phosphorylation at Thr701
por: Chen, Chia‐Hung, et al.
Publicado: (2017)

The Effects of Pertuzumab and Its Combination with Trastuzumab on HER2 Homodimerization and Phosphorylation
por: Nami, Babak, et al.
Publicado: (2019)

CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas
por: Pita, Jaime M., et al.
Publicado: (2023)

Nurses’ Experiences of Caring for Long-Term Care Residents With Dementia During the COVID-19 Pandemic
por: Scerri, Anthony, et al.
Publicado: (2022)

Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines
por: Burguin, Anna, et al.
Publicado: (2020)

Leptin Inhibits Glucose Intestinal Absorption via PKC, p38MAPK, PI3K and MEK/ERK
por: El-Zein, Ola, et al.
Publicado: (2013)

Correction: Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines
Publicado: (2020)

MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation
por: Baranski, Zuzanna, et al.
Publicado: (2015)

A Study on Selection Performance for High Energy Photons in CMS towards the 13 TeV LHC Run
por: Scerri, Dale
Publicado: (2014)

30-second elements: the 50 most significant elements, each explained in half a minute
por: Scerri, Eric
Publicado: (2013)

Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner
por: Julku, Ulrika H., et al.
Publicado: (2021)

Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer
por: Nafi, Siti Norasikin Mohd, et al.
Publicado: (2014)

The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation
por: Gough, Daniel J., et al.
Publicado: (2013)

Illness perceptions, depression and anxiety in informal carers of persons with depression: a cross-sectional survey
por: Scerri, Josianne, et al.
Publicado: (2018)

Time to act! A review exploring the impact of climate change on respiratory diseases
por: Scerri, K, et al.
Publicado: (2023)

Differential phosphorylation of NG2 proteoglycan by ERK and PKCα helps balance cell proliferation and migration
por: Makagiansar, Irwan T., et al.
Publicado: (2007)

Correction: The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation
por: Gough, Daniel J., et al.
Publicado: (2013)

Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK
por: Hey, Fiona, et al.
Publicado: (2018)

The MEK/ERK Module Is Reprogrammed in Remodeling Adult Cardiomyocytes
por: Thomas, Kubin, et al.
Publicado: (2020)

Non-coding RNA influences in dementia
por: Ayers, Duncan, et al.
Publicado: (2018)

Navigating the Storm to Recovery through the Pictorial Representations of Persons in the Recovery Phase from Unipolar Depression
por: Scerri, Josianne, et al.
Publicado: (2022)

PPP1R14D promotes the proliferation, migration and invasion of lung adenocarcinoma via the PKCα/BRAF/MEK/ERK signaling pathway
por: Cao, Huijun, et al.
Publicado: (2022)

Serum regulates adipogenesis of mesenchymal stem cells via MEK/ERK-dependent PPARγ expression and phosphorylation
por: Wu, Ling, et al.
Publicado: (2010)

MEK/ERK addiction in CNL/aCML
por: Kesarwani, Meenu, et al.
Publicado: (2017)

Re-enforcing the strategy of targeting MEK/ERK signaling to overcome acquired resistance to third generation EGFR inhibitors
por: Zhao, Wen, et al.
Publicado: (2021)

Upregulation of ADAM proteases and HER ligands through a feedback loop mediates acquired resistance to trastuzumab in HER2-amplified breast cancer
por: Gijsen, M, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_n8dgirvrii2bofu372n57e30oe