Chemotherapy induces feedback up-regulation of CD44v6 in colorectal cancer initiating cells through β-catenin/MDR1 signaling to sustain chemoresistance

Chemoresistance in colorectal cancer initiating cells (CICs) involves the sustained activation of multiple drug resistance (MDR) and WNT/β-catenin signaling pathways, as well as of alternatively spliced-isoforms of CD44 containing variable exon-6 (CD44v6). In spite of its importance, mechanisms unde...

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Detalles Bibliográficos
Autores principales: Ghatak, Shibnath, Hascall, Vincent C., Karamanos, Nikos, Markwald, Roger R., Misra, Suniti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623568/
https://www.ncbi.nlm.nih.gov/pubmed/36330477
http://dx.doi.org/10.3389/fonc.2022.906260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623568/
https://www.ncbi.nlm.nih.gov/pubmed/36330477
http://dx.doi.org/10.3389/fonc.2022.906260

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