Cargando…
Potent and biostable inhibitors of the main protease of SARS-CoV-2
Potent and biostable inhibitors of the main protease (M(pro)) of SARS-CoV-2 were designed and synthesized based on an active hit compound 5h (2). Our strategy was based not only on the introduction of fluorine atoms into the inhibitor molecule for an increase of binding affinity for the pocket of M(...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623849/ https://www.ncbi.nlm.nih.gov/pubmed/36338434 http://dx.doi.org/10.1016/j.isci.2022.105365 |