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Supercoiling-mediated feedback rapidly couples and tunes transcription
Transcription induces a wave of DNA supercoiling, altering the binding affinity of RNA polymerases and reshaping the biochemical landscape of gene regulation. As supercoiling rapidly diffuses, transcription dynamically reshapes the regulation of proximal genes, forming a complex feedback loop. Howev...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624111/ https://www.ncbi.nlm.nih.gov/pubmed/36261020 http://dx.doi.org/10.1016/j.celrep.2022.111492 |