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Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model
RAS GTPases are ubiquitous GDP/GTP-binding proteins that function as molecular switches in cellular signalling and control numerous signalling pathways and biological processes. Pathogenic mutations in RAS genes severely affect cellular homeostasis, leading to cancer when occurring in somatic cells...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624175/ https://www.ncbi.nlm.nih.gov/pubmed/36330334 http://dx.doi.org/10.3389/fcell.2022.1000575 |