Divergent outcomes of anti-PD-L1 treatment coupled with host-intrinsic differences in TCR repertoire and distinct T cell activation states in responding versus non-responding tumors

Differential responses to immune checkpoint inhibitors (ICI) may be attributed to tumor-intrinsic factors or environmental cues; however, these mechanisms cannot fully explain the variable ICI responses in different individuals. Here, we investigate the potential contribution of immunological hetero...

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Detalles Bibliográficos
Autores principales: John, Jessy, Woolaver, Rachel A., Popolizio, Vince, Chen, Samantha M. Y., Ge, Huaibin, Krinsky, Alexandra L., Vashisht, Monika, Kramer, Yonatan, Chen, Zhangguo, Wang, Jing H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624473/
https://www.ncbi.nlm.nih.gov/pubmed/36330507
http://dx.doi.org/10.3389/fimmu.2022.992630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624473/
https://www.ncbi.nlm.nih.gov/pubmed/36330507
http://dx.doi.org/10.3389/fimmu.2022.992630

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