OR10-1 Body Mass Index and Weight Reductions in Patients With Obesity Due to Heterozygous Variants in POMC, PCSK1, and LEPR After 1 Year of Setmelanotide

BACKGROUND: The melanocortin-4 receptor (MC4R) pathway is a key regulator of energy balance. Heterozygous variants of the genes for proopiomelanocortin (POMC), leptin receptor (LEPR), and proprotein convertase subtilisin/kexin type 1 (PCSK1) upstream of MC4R can result in impaired signaling in the M...

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Detalles Bibliográficos
Autores principales: Farooqi, Sadaf, Miller, Jennifer, Ohayan, Olga, Scimia, Cecilia, Still, Christopher, Yohn, Marianne, Yuan, Guojun, Argente, Jesús, Buckley, Brieana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Adipose Tissue, Appetite, & Obesity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624614/
http://dx.doi.org/10.1210/jendso/bvac150.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624614/
http://dx.doi.org/10.1210/jendso/bvac150.031

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