RF24 | PSUN91 Body Mass Index and Weight Reduction in Patients With SH2B1 Genetic Variant Obesity After One Year of Setmelanotide

BACKGROUND: SH2B adaptor protein 1 (SH2B1) binds to Janus kinase 2 and enhances leptin signaling through the central melanocortin-4 receptor (MC4R) pathway, a key regulator of energy balance. Variants in SH2B1 or a 220–kilobase pair distal deletion of chromosome 16p11.2, including SH2B1, are associa...

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Detalles Bibliográficos
Autores principales: Argente, Jesús, Farooqi, Sadaf, Chung, Wendy, Wabitsch, Martin, Scimia, Cecilia, Srinivasan, Madhura, Hu, Shuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Adipose Tissue, Appetite, & Obesity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624738/
http://dx.doi.org/10.1210/jendso/bvac150.073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624738/
http://dx.doi.org/10.1210/jendso/bvac150.073

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