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RF24 | PSUN91 Body Mass Index and Weight Reduction in Patients With SH2B1 Genetic Variant Obesity After One Year of Setmelanotide

BACKGROUND: SH2B adaptor protein 1 (SH2B1) binds to Janus kinase 2 and enhances leptin signaling through the central melanocortin-4 receptor (MC4R) pathway, a key regulator of energy balance. Variants in SH2B1 or a 220–kilobase pair distal deletion of chromosome 16p11.2, including SH2B1, are associa...

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Detalles Bibliográficos
Autores principales:	Argente, Jesús, Farooqi, Sadaf, Chung, Wendy, Wabitsch, Martin, Scimia, Cecilia, Srinivasan, Madhura, Hu, Shuang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Adipose Tissue, Appetite, & Obesity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624738/ http://dx.doi.org/10.1210/jendso/bvac150.073

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