OR24-6 Liver-Specific Inhibition of Sialic Acid Biosynthesis Improves Systemic Glucose Homeostasis in Mice

Glycosylation is an important posttranslational modification that modulates protein expression and function. Sialic acid is the most abundant terminal monosaccharide of N-linked glycosylation in mammalian cells, and its biosynthesis is controlled by the rate-limited enzyme UDP-GlcNAc 2-epimerase/Man...

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Detalles Bibliográficos
Autores principales: Holland, William, Kohler, Jennifer, Mineo, Chieko, Oh, Dayoung, Shaul, Philip, Yu, Liming, Peng, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Diabetes & Glucose Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624826/
http://dx.doi.org/10.1210/jendso/bvac150.734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624826/
http://dx.doi.org/10.1210/jendso/bvac150.734

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