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OR19-5 Dissecting Thyroidal Pathways Activated by PD-L1 Blockade Identifies New Mechanisms for Thyroiditis Triggered by Immune Checkpoint Inhibitors

Programmed death-ligand 1 (PD-L1) is a strong immunosuppressor that inhibits T-cell activation by binding to its receptor (PD-1) on T-cells. Blocking the PD-L1/PD-1 interaction by monoclonal antibodies (mAbs) is an effective therapy for several cancers via activation of T-cells. Destructive thyroidi...

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Detalles Bibliográficos
Autores principales: Hou, Hanxi, Li, Cheuk Wun, Tomer, Yaron, Yi, Zhengzi, Zhang, Weijia, Stefan Lifshitz, Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625301/
http://dx.doi.org/10.1210/jendso/bvac150.1660