OR27-4 Placebo-Controlled and Open-Label Extension Study of a Novel Hepatic-Targeted Antisense Cimdelirsen (IONIS-GHR-LRx) Under Investigation in Acromegaly Patients

 : Cimdelirsen (IONIS-GHR-LRx; ISIS 766720) is a novel, ligand-conjugated, hepatic-targeted investigative antisense molecule designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like...

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Detalles Bibliográficos
Autores principales: Bhanot, Sanjay, Fleseriu, Maria, Geary, Richard, Hu, Kuolung, Li, Lu, Melmed, Shlomo, Trunfio, Julia, Waldman, Elaine, Morgan, Erin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Neuroendocrinology and Pituitary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625484/
http://dx.doi.org/10.1210/jendso/bvac150.1095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625484/
http://dx.doi.org/10.1210/jendso/bvac150.1095

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