LBMON186 Beta-agonist Profiling Reveals Novel Biased Signaling Phenotypes For The Beta 2-adrenergic Receptor With Implications In The Treatment Of Asthma

Asthma involves chronic airway inflammation and airway smooth muscle (ASM) cell contraction. Treatment include agonists of the beta 2-AR, a GPCR that induces the Gs/cAMP pathway leading to ASM relaxation. These agonists can also promote severe side effects which have been correlated with beta-arrest...

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Detalles Bibliográficos
Autores principales: Pascali, Francesco D, Ippolito, Michael, Wolfe, Emily, Komolov, Konstantin E, Hopfinger, Nathan, Lemenze, Douglas, Kim, Nicholas, Armen, Roger S, An, Steven S, Scott, Charles P, Benovic, Jeffrey L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Non-Steroid Hormone Signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625524/
http://dx.doi.org/10.1210/jendso/bvac150.1217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625524/
http://dx.doi.org/10.1210/jendso/bvac150.1217

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