OR14-5 Branched-chain Amino Acid and Tryptophan Metabolism and the Pathogenesis of Youth-Onset Type 2 Diabetes Mellitus (T2D)

OBJECTIVES: We have previously demonstrated that insulin resistance (IR) in youth is associated with elevated levels of branched-chain amino acids (BCAAs). BCAAs compete with aromatic amino acids (AAA) including tryptophan, the precursor of serotonin, for uptake into β-cells and other tissues via th...

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Detalles Bibliográficos
Autores principales: Armstrong, Sarah, Bain, James R, Crawford, Matthew, Freemark, Michael, Grant, Russell P, Gumus Balikcioglu, Pinar, Hsia, Daniel S, Ilkayeva, Olga, Jain, Nina, Muehlbauer, Michael, Newgard, Christopher, Ramaker, Megan, Delgado, Natalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Pediatric Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625596/
http://dx.doi.org/10.1210/jendso/bvac150.1275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625596/
http://dx.doi.org/10.1210/jendso/bvac150.1275

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