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Immune mobilising T cell receptors redirect polyclonal CD8(+) T cells in chronic HIV infection to form immunological synapses

T cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8(+) T cells, which may remain dysfunctional despite viral load-reducing antiretroviral therapy; however, abnormalities may...

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Detalles Bibliográficos
Autores principales: Wallace, Zoë, Kopycinski, Jakub, Yang, Hongbing, McCully, Michelle L., Eggeling, Christian, Chojnacki, Jakub, Dorrell, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626491/
https://www.ncbi.nlm.nih.gov/pubmed/36319836
http://dx.doi.org/10.1038/s41598-022-23228-3