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DNA read count calibration for single-molecule, long-read sequencing
There are many applications in which quantitative information about DNA mixtures with different molecular lengths is important. Gene therapy vectors are much longer than can be sequenced individually via short-read NGS. However, vector preparations may contain smaller DNAs that behave differently du...
Autores principales: | Soares, Luis M. M., Hanscom, Terrence, Selby, Donald E., Adjei, Samuel, Wang, Wei, Przybylski, Dariusz, Thompson, John F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626564/ https://www.ncbi.nlm.nih.gov/pubmed/36319642 http://dx.doi.org/10.1038/s41598-022-21606-5 |
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