Tumor Apolipoprotein E is a key checkpoint blocking anti-tumor immunity in mouse melanoma

Immunotherapy is a key modality in the treatment of cancer, but many tumors remain immune resistant. The classic mouse model of B16-F10 melanoma is immune resistant even in the face of checkpoint inhibition. Apolipoprotein E (apoE), a known immune suppressant is strikingly elevated in many human tum...

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Detalles Bibliográficos
Autores principales: Wu, Xiaofang, Srinivasan, Priya, Basu, Mousumi, Zhang, Peng, Saruwatari, Michele, Thommandru, Bernice, Jacobi, Ashley, Behlke, Mark, Sandler, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626815/
https://www.ncbi.nlm.nih.gov/pubmed/36341364
http://dx.doi.org/10.3389/fimmu.2022.991790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626815/
https://www.ncbi.nlm.nih.gov/pubmed/36341364
http://dx.doi.org/10.3389/fimmu.2022.991790

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