Distinct Mechanisms for Increased Cardiac Contraction Through Selective Alteration of Either Myosin or Troponin Activity

Modulation of sarcomere contractility represents a new therapeutic opportunity for the treatment of heart failure by directly targeting the thick and thin filament proteins of the sarcomere to increase cardiac muscle contraction. This study compared the effect of 2 small molecules (M and T) that sel...

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Detalles Bibliográficos
Autores principales: Singh, Rohit R., Slater, Rebecca E., Wang, Jinghong, Wang, Chen, Guo, Qi, Motani, Alykhan S., Hartman, James J., Sadayappan, Sakthivel, Ason, Brandon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626889/
https://www.ncbi.nlm.nih.gov/pubmed/36337919
http://dx.doi.org/10.1016/j.jacbts.2022.04.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626889/
https://www.ncbi.nlm.nih.gov/pubmed/36337919
http://dx.doi.org/10.1016/j.jacbts.2022.04.013

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