MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer

Immunotherapy has shown limited efficacy in patients with EGFR-mutated lung cancer. Efforts to enhance the immunogenicity of EGFR-mutated lung cancer have been unsuccessful to date. Here, we discover that MET amplification, the most common mechanism of resistance to third-generation EGFR tyrosine ki...

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Detalles Bibliográficos
Autores principales: Yoshida, Ryohei, Saigi, Maria, Tani, Tetsuo, Springer, Benjamin F., Shibata, Hirofumi, Kitajima, Shunsuke, Mahadevan, Navin R., Campisi, Marco, Kim, William, Kobayashi, Yoshihisa, Thai, Tran C., Haratani, Koji, Yamamoto, Yurie, Sundararaman, Shriram K., Knelson, Erik H., Vajdi, Amir, Canadas, Israel, Uppaluri, Ravindra, Paweletz, Cloud P., Miret, Juan J., Lizotte, Patrick H., Gokhale, Prafulla C., Jänne, Pasi A., Barbie, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627131/
https://www.ncbi.nlm.nih.gov/pubmed/36066413
http://dx.doi.org/10.1158/0008-5472.CAN-22-0770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627131/
https://www.ncbi.nlm.nih.gov/pubmed/36066413
http://dx.doi.org/10.1158/0008-5472.CAN-22-0770

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