VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma

Synthetic lethality is a genetic interaction that results in cell death when two genetic deficiencies co-occur but not when either deficiency occurs alone, which can be co-opted for cancer therapeutics. Pairs of paralog genes are among the most straightforward potential synthetic–lethal interactions...

Descripción completa

Detalles Bibliográficos
Autores principales: Shields, Julie A., Meier, Samuel R., Bandi, Madhavi, Mulkearns-Hubert, Erin E., Hajdari, Nicole, Ferdinez, Maria Dam, Engel, Justin L., Silver, Daniel J., Shen, Binzhang, Zhang, Wenhai, Hubert, Christopher G., Mitchell, Kelly, Shakya, Sajina, Zhao, Shan-Chuan, Bejnood, Alborz, Zhang, Minjie, Tjin Tham Sjin, Robert, Wilker, Erik, Lathia, Justin D., Andersen, Jannik N., Chen, Yingnan, Li, Fang, Weber, Barbara, Huang, Alan, Emmanuel, Natasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Tumor Biology and Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627132/
https://www.ncbi.nlm.nih.gov/pubmed/36069976
http://dx.doi.org/10.1158/0008-5472.CAN-21-4443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627132/
https://www.ncbi.nlm.nih.gov/pubmed/36069976
http://dx.doi.org/10.1158/0008-5472.CAN-21-4443

Ejemplares similares