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VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma

Synthetic lethality is a genetic interaction that results in cell death when two genetic deficiencies co-occur but not when either deficiency occurs alone, which can be co-opted for cancer therapeutics. Pairs of paralog genes are among the most straightforward potential synthetic–lethal interactions...

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Detalles Bibliográficos
Autores principales:	Shields, Julie A., Meier, Samuel R., Bandi, Madhavi, Mulkearns-Hubert, Erin E., Hajdari, Nicole, Ferdinez, Maria Dam, Engel, Justin L., Silver, Daniel J., Shen, Binzhang, Zhang, Wenhai, Hubert, Christopher G., Mitchell, Kelly, Shakya, Sajina, Zhao, Shan-Chuan, Bejnood, Alborz, Zhang, Minjie, Tjin Tham Sjin, Robert, Wilker, Erik, Lathia, Justin D., Andersen, Jannik N., Chen, Yingnan, Li, Fang, Weber, Barbara, Huang, Alan, Emmanuel, Natasha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Tumor Biology and Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627132/ https://www.ncbi.nlm.nih.gov/pubmed/36069976 http://dx.doi.org/10.1158/0008-5472.CAN-21-4443

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