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Developmental Deconvolution for Classification of Cancer Origin

Cancer is partly a developmental disease, with malignancies named based on cell or tissue of origin. However, a systematic atlas of tumor origins is lacking. Here we map the single-cell organogenesis of 56 developmental trajectories to the transcriptomes of over 10,000 tumors across 33 cancer types....

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Detalles Bibliográficos
Autores principales: Moiso, Enrico, Farahani, Alexander, Marble, Hetal D., Hendricks, Austin, Mildrum, Samuel, Levine, Stuart, Lennerz, Jochen K., Garg, Salil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627133/
https://www.ncbi.nlm.nih.gov/pubmed/36041084
http://dx.doi.org/10.1158/2159-8290.CD-21-1443