Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia

The chromatin reader eleven–nineteen leukemia (ENL) has been identified as a critical dependency in acute myeloid leukemia (AML), but its therapeutic potential remains unclear. We describe a potent and orally bioavailable small-molecule inhibitor of ENL, TDI-11055, which displaces ENL from chromatin...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yiman, Li, Qinglan, Alikarami, Fatemeh, Barrett, Declan R., Mahdavi, Leila, Li, Hangpeng, Tang, Sylvia, Khan, Tanweer A., Michino, Mayako, Hill, Connor, Song, Lele, Yang, Lu, Li, Yuanyuan, Pokharel, Sheela Pangeni, Stamford, Andrew W., Liverton, Nigel, Renzetti, Louis M., Taylor, Simon, Watt, Gillian F., Ladduwahetty, Tammy, Kargman, Stacia, Meinke, Peter T., Foley, Michael A., Shi, Junwei, Li, Haitao, Carroll, Martin, Chen, Chun-Wei, Gardini, Alessandro, Maillard, Ivan, Huggins, David J., Bernt, Kathrin M., Wan, Liling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627135/
https://www.ncbi.nlm.nih.gov/pubmed/36053276
http://dx.doi.org/10.1158/2159-8290.CD-21-1307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627135/
https://www.ncbi.nlm.nih.gov/pubmed/36053276
http://dx.doi.org/10.1158/2159-8290.CD-21-1307

Ejemplares similares