RF15 | PMON294 Disrupting a Key H-bond Network Drives Glucocorticoid Receptor Gene Suppression Without Off-target Gene Activation for Duchenne Muscular Dystrophy Treatment

Duchenne muscular dystrophy is a genetic disorder that shows chronic and progressive damage to skeletal and cardiac muscle leading to premature death. Anti-inflammatory corticosteroids targeting the glucocorticoid receptor (GR) are the current standard of care but drive adverse side effects such as...

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Detalles Bibliográficos
Autores principales: Liu, Xu, Hoffman, Eric, Ortlund, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Steroid Hormones and Receptors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627259/
http://dx.doi.org/10.1210/jendso/bvac150.1516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627259/
http://dx.doi.org/10.1210/jendso/bvac150.1516

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