Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals

Excessive generation of reactive oxygen species (ROS) has great impacts on MSU crystal-induced inflammation. Drp1-dependent mitochondrial fission is closely associated with mitochondrial ROS levels. However, whether Drp1 signaling contributes to MSU crystal-induced inflammation remains unclear. Mice...

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Detalles Bibliográficos
Autores principales: Jiang, Hui, Chen, Feng, Song, DianZe, Zhou, Xiaoqin, Ren, Long, Zeng, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627272/
https://www.ncbi.nlm.nih.gov/pubmed/36338340
http://dx.doi.org/10.1155/2022/5064494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627272/
https://www.ncbi.nlm.nih.gov/pubmed/36338340
http://dx.doi.org/10.1155/2022/5064494

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