Molecular iodine-promoted oxidative cyclization for the synthesis of 1,3,4-thiadiazole-fused- [1,2,4]-thiadiazole incorporating 1,4-benzodioxine moiety as potent inhibitors of α-amylase and α-glucosidase: In vitro and in silico study

Twenty-five analogs were synthesized based on 1,3,4-thiadiazole-fused-[1,2,4]-thiadiazole incorporating 1,4-benzodioxine moiety (1–25) and then tested for the antidiabetic profile. The entire afforded derivatives showed varied inhibition profiles ranging between 0.70 ± 0.01 and 30.80 ± 0.80 μM (agai...

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Detalles Bibliográficos
Autores principales: Hussain, Rafaqat, Shah, Mazloom, Iqbal, Shahid, Rehman, Wajid, Khan, Shoaib, Rasheed, Liaqat, Naz, Haseena, Al-ghulikah, Hanan A., Elkaeed, Eslam B., Pashameah, Rami Adel, Alzahrani, Eman, Farouk, Abd-ElAziem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627624/
https://www.ncbi.nlm.nih.gov/pubmed/36339037
http://dx.doi.org/10.3389/fchem.2022.1023316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627624/
https://www.ncbi.nlm.nih.gov/pubmed/36339037
http://dx.doi.org/10.3389/fchem.2022.1023316

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