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m6A is required for resolving progenitor identity during planarian stem cell differentiation

Regeneration and tissue homeostasis require accurate production of missing cell lineages. Cell production is driven by changes to gene expression, which is shaped by multiple layers of regulation. Here, we find that the ubiquitous mRNA base‐modification, m6A, is required for proper cell fate choice...

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Detalles Bibliográficos
Autores principales: Dagan, Yael, Yesharim, Yarden, Bonneau, Ashley R, Frankovits, Tamar, Schwartz, Schraga, Reddien, Peter W, Wurtzel, Omri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627665/
https://www.ncbi.nlm.nih.gov/pubmed/35971838
http://dx.doi.org/10.15252/embj.2021109895