TSG101 associates with PARP1 and is essential for PARylation and DNA damage‐induced NF‐κB activation

In a genome‐wide screening for components of the dsDNA‐break‐induced IKK‐NF‐κB pathway, we identified scores of regulators, including tumor susceptibility gene TSG101. TSG101 is essential for DNA damage‐induced formation of cellular poly(ADP‐ribose) (PAR). TSG101 binds to PARP1 and is required for P...

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Detalles Bibliográficos
Autores principales: Tufan, Ahmet Buğra, Lazarow, Katina, Kolesnichenko, Marina, Sporbert, Anje, von Kries, Jens Peter, Scheidereit, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627669/
https://www.ncbi.nlm.nih.gov/pubmed/36124865
http://dx.doi.org/10.15252/embj.2021110372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627669/
https://www.ncbi.nlm.nih.gov/pubmed/36124865
http://dx.doi.org/10.15252/embj.2021110372

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