A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

Sirtuin 6 (SIRT6) is a deacylase and mono‐ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in aging and metabolism regulation. Targeted sequencing of SIRT6 locus in a population of 450 Ashkenazi Jewish (AJ) centenarians and 550 AJ individuals without a family...

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Detalles Bibliográficos
Autores principales: Simon, Matthew, Yang, Jiping, Gigas, Jonathan, Earley, Eric J, Hillpot, Eric, Zhang, Lei, Zagorulya, Maria, Tombline, Greg, Gilbert, Michael, Yuen, Samantha L, Pope, Alexis, Van Meter, Michael, Emmrich, Stephan, Firsanov, Denis, Athreya, Advait, Biashad, Seyed Ali, Han, Jeehae, Ryu, Seungjin, Tare, Archana, Zhu, Yizhou, Hudgins, Adam, Atzmon, Gil, Barzilai, Nir, Wolfe, Aaron, Moody, Kelsey, Garcia, Benjamin A, Thomas, David D, Robbins, Paul D, Vijg, Jan, Seluanov, Andrei, Suh, Yousin, Gorbunova, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627671/
https://www.ncbi.nlm.nih.gov/pubmed/36215696
http://dx.doi.org/10.15252/embj.2021110393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627671/
https://www.ncbi.nlm.nih.gov/pubmed/36215696
http://dx.doi.org/10.15252/embj.2021110393

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