ODP646 Deficient NNT Reduces Mitochondrial Mass and Cholesterol Trafficking in the Adrenal Cortex, Accumulating ROS and Impairing Steroids Production

BACKGROUND: The mitochondrial enzyme nicotinamide nucleotide transhydrogenase (NNT) is essential in the antioxidant defense mechanisms. In addition, adrenal cortex cells appear to require NNT for normal steroidogenesis. However, to date, the mechanisms involved in NNT regulation of steroidogenesis a...

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Detalles Bibliográficos
Autores principales: Antonini, Sonir, Bodoni, Aline Faccioli, Coeli-Lacchini, Fernanda, Gebenlian, Juliana L, Moreira, Ayrton C, Elias, Lucila L, Junior, Wilson Araujo Silva, Castro, Margaret, Leopoldino, Andreia Machado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Adrenal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627747/
http://dx.doi.org/10.1210/jendso/bvac150.163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627747/
http://dx.doi.org/10.1210/jendso/bvac150.163

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