Cargando…

ODP646 Deficient NNT Reduces Mitochondrial Mass and Cholesterol Trafficking in the Adrenal Cortex, Accumulating ROS and Impairing Steroids Production

BACKGROUND: The mitochondrial enzyme nicotinamide nucleotide transhydrogenase (NNT) is essential in the antioxidant defense mechanisms. In addition, adrenal cortex cells appear to require NNT for normal steroidogenesis. However, to date, the mechanisms involved in NNT regulation of steroidogenesis a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Antonini, Sonir, Bodoni, Aline Faccioli, Coeli-Lacchini, Fernanda, Gebenlian, Juliana L, Moreira, Ayrton C, Elias, Lucila L, Junior, Wilson Araujo Silva, Castro, Margaret, Leopoldino, Andreia Machado
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Adrenal
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627747/ http://dx.doi.org/10.1210/jendso/bvac150.163

Ejemplares similares

SAT-LB067 Mutational Spectrum Determines Subtle Adrenal Biosynthetic Defect in Non-Classical Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
por: Mermejo, Livia, et al.
Publicado: (2019)

SAT-LB36 Distinct Vitamin D Receptor DNA Methylation Profiles Are Associated With the Outcome of Pediatric Patients With Adrenocortical Tumors
por: Bueno, Ana Carolina, et al.
Publicado: (2020)

SAT-179 Increased Telomere Length in Adrenocortical Tumors Is Associated with Abnormal Expression of Chromatin Remodelling Factors
por: Stecchini, Monica F, et al.
Publicado: (2020)

SAT-353 The Synthetic Vitamin D Analog EB1089 Restricts Adrenocortical Tumor Proliferation in NCI-H295 Xenograft Model
por: Bueno, Ana, et al.
Publicado: (2019)

OR02-4 YAP1 Overexpression Associates With Worse Prognosis In Patients With Adrenal Tumors And YAP1 Inhibition By Verteporfin Reduces Tumorigenicity And Reverses Epithelial-mesenchymal Transition In Adrenocortical Tumor Cells
por: Bellido More, Candy, et al.
Publicado: (2019)

ODP436 Adrenal Insufficiency After Combined Treatment of Itraconazole and Triamcinolone
por: Sajan, Alen, et al.
Publicado: (2022)

ODP056 The Treatment of Opioid Addiction Leading to Secondary Adrenal Insufficiency
por: Morgan, Farah, et al.
Publicado: (2022)

ODP066 Impact of Comorbid Adrenal Insufficiency on Outcomes of Infective Endocarditis Hospitalizations
por: Akaho, Elikplim, et al.
Publicado: (2022)

ODP059 Torn Between Two Adrenal Cancers: A Case Report
por: Beronio, Rae Angeli, et al.
Publicado: (2022)

ODP016 A case of adrenal incidentaloma in a patient with latent tuberculosis
por: Musurakis, Clio, et al.
Publicado: (2022)

ODP638 Towards the development of treatment planning for microwave thermal ablation of adrenal adenomas
por: Cappiello, Grazia, et al.
Publicado: (2022)

ODP580 A Case of New Onset Primary Adrenal Insufficiency in COVID Infection
por: Beshay, Lauren, et al.
Publicado: (2022)

ODP639 The Occurrence and Predictors of Postoperative Adrenal Insufficiency for Patients With Subclinical Cushing's Syndrome
por: Da-long, Zhu, et al.
Publicado: (2022)

ODP065 Impact of Comorbid Adrenal Insufficiency on Outcomes During Hospitalization For Cardiogenic Shock
por: Kumi, Dennis D, et al.
Publicado: (2022)

ODP631 Infectious Disease Causing Damage Of The Adrenal Glands, A Life Threating Event
por: Saleem, Marwa, et al.
Publicado: (2022)

ODP020 A Challenging Case of Poorly Differentiated Carcinoma with Neuroendocrine Differentiation and Adrenal Mass
por: Mosquera, Jorge, et al.
Publicado: (2022)

ODP023 Adrenal medullary hyperplasia as a differential diagnosis of paroxysmal hypertension: case report
por: de Abreu Toniolo, Paula, et al.
Publicado: (2022)

ODP037 Effects of DHCR24 Inhibitor on Excessive Adrenal Steroidogenesis in db/db mouse
por: Kamigaki, Risa, et al.
Publicado: (2022)

ODP018 A Case of Cushing's Syndrome due to Primary Bilateral Macronodular Adrenal Hyperplasia
por: Veluru, Manasa, et al.
Publicado: (2022)

ODP028 Association Between Serum Steroid Profile and Metabolic Risks in Adults with Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
por: Ahn, Chang H, et al.
Publicado: (2022)

ODP030 Autoimmune Adrenalitis Following mRNA Covid- 19 Immunization In A Patient Without A Known Diagnosis Of Adrenal Insufficiency.
por: Jamal, Yusra, et al.
Publicado: (2022)

ODP063 Development and Validation of Model for Sparing Adrenal Venous Sampling in Diagnosing Unilateral Primary Aldosteronism
por: Hu, Jinbo, et al.
Publicado: (2022)

ODP048 Large Bilateral Adrenal Lesions Abutting Right Hemidiaphragm in a Man from Texas
por: Gosmanova, Albina, et al.
Publicado: (2022)

ODP035 Congenital Adrenal Hyperplasia secondary to 3 beta hydroxydehydrogenase deficiency: Case study and review of literature
por: Alkhaddo, Jamil, et al.
Publicado: (2022)

ODP596 Central Adrenal Insufficiency After Intra-Articular Triamcinolone Injection In A Patient On Dolutegravir And Cobicistat Boosted Darunavir
por: Chen, Ying, et al.
Publicado: (2022)

ODP054 The Impact of SGLT2-inhibitors on Renin-Aldosterone axis and Adrenal Incidentaloma's work up: Case study and literature review
por: Alkhaddo, Jamil, et al.
Publicado: (2022)

ODP034 Circulating Protein Biomarkers for Discriminating Malignant from Benign Adrenal Tumors Using Mass Spectrometry-Based Proteomic Analysis
por: Park, Seung Shin, et al.
Publicado: (2022)

ODP144 Cushing Syndrome and Primary Hyperaldosteronism due to Synchronic Bilateral Adrenal Adenomas with Exclusive Production of Cortisol on the Right and Aldosterone on the Left
por: Rolim, Marina Rocha, et al.
Publicado: (2022)

SAT343 Nicotinamide Nucleotide Transhydrogenase (NNT)-related Familial Glucocorticoid Deficiency: More Than Adrenal Insufficiency
por: Shanker, Anita, et al.
Publicado: (2023)

SAT-173 SAMD9 (Sterile Alpha Motif Domain-Containing 9) Expression in Adrenocortical Tumors
por: Bueno, Ana C, et al.
Publicado: (2020)

ODP055 The methylation pattern of a unique Bilateral para-overian Adrenal Rest Tumor in a girl with Nicotinamide Nucleotide Transhydrogenase mutation
por: Cahn, Ranit, et al.
Publicado: (2022)

ODP045 Implantation of Steroidogenic Cells Derived from Human Adipose-derived Stem Cells Extends Survival in a Mouse Model of Adrenal Insufficiency
por: Tanaka, Tomoko, et al.
Publicado: (2022)

ODP015 "Malignant" Hypertension in an Older Male
por: Naha, Sowjanya, et al.
Publicado: (2022)

ODP586 Analysis of Adrenal Vein Sampling (AVS) Success: A Retrospective Study of Primary Aldosteronism Patients at the National University of Malaysia (UKM) Medical Center
por: Azizan, Elena Aisha, et al.
Publicado: (2022)

ODP062 Clinical Outcomes of Cardiogenic Shock Hospitalization Among Patients with Long-term Systemic Steroid Use
por: Kumi, Dennis D, et al.
Publicado: (2022)

ODP621 Hypertension with Hypokalemia in Pregnancy? Think "Cushing's Syndrome"
por: Al Tameemi, Mohammed, et al.
Publicado: (2022)

ODP067 Long-term Systemic Steroid Use And Its Impact on In-hospital Outcomes Among Patients Admitted With Acute Pericarditis
por: Kumi, Dennis, et al.
Publicado: (2022)

ODP049 Oncocytic adrenocortical carcinoma misdiagnosed as renal oncocytoma and use of urinary steroid profiling in disease monitoring after mitotane therapy
por: Wong, Cheuk Lik, et al.
Publicado: (2022)

ODP041 Hearing Loss Reveals Dopamine-secreting Metastatic Paraganglioma
por: Cutrone, Lauren S, et al.
Publicado: (2022)

ODP025 Adrenocortical Carcinoma: A Rare but Life-Threatening Malignancy
por: Ortiz-Rivera, Monica, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_umdjpe45inca8gctbtmnkroj2l