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Resistance to DNA repair inhibitors in cancer

The DNA damage response (DDR) represents a complex network of proteins which detect and repair DNA damage, thereby maintaining the integrity of the genome and preventing the transmission of mutations and rearranged chromosomes to daughter cells. Faults in the DDR are a known driver and hallmark of c...

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Detalles Bibliográficos
Autores principales: Baxter, Joseph S., Zatreanu, Diana, Pettitt, Stephen J., Lord, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627783/
https://www.ncbi.nlm.nih.gov/pubmed/35567571
http://dx.doi.org/10.1002/1878-0261.13224