Cargando…

Fragment‐based drug discovery—the importance of high‐quality molecule libraries

Fragment‐based drug discovery (FBDD) is now established as a complementary approach to high‐throughput screening (HTS). Contrary to HTS, where large libraries of drug‐like molecules are screened, FBDD screens involve smaller and less complex molecules which, despite a low affinity to protein targets...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bon, Marta, Bilsland, Alan, Bower, Justin, McAulay, Kirsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627785/ https://www.ncbi.nlm.nih.gov/pubmed/35749608 http://dx.doi.org/10.1002/1878-0261.13277

Ejemplares similares

Reactivity of Covalent Fragments and Their Role in Fragment Based Drug Discovery
por: McAulay, Kirsten, et al.
Publicado: (2022)

Implementation of an AI-assisted fragment-generator in an open-source platform
por: Bilsland, Alan E., et al.
Publicado: (2022)

Fragment Library of Natural Products and Compound Databases for Drug Discovery †
por: Chávez-Hernández, Ana L., et al.
Publicado: (2020)

Military laser technology for defense: technology for revolutionizing 21st century warfare
por: McAulay, Alastair D
Publicado: (2011)

Fluticasone/formoterol combination therapy is as effective as fluticasone/salmeterol in the treatment of asthma, but has a more rapid onset of action: an open-label, randomized study
por: Bodzenta-Lukaszyk, Anna, et al.
Publicado: (2011)

Generating Focused Molecule Libraries for Drug Discovery with Recurrent Neural Networks
por: Segler, Marwin H. S., et al.
Publicado: (2017)

High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery
por: Ayon, Navid J.
Publicado: (2023)

Adolescent Depression from a Developmental Perspective: The Importance of Recognizing Developmental Distress in Depressed Adolescents
por: Rikard-Bell, Christopher, et al.
Publicado: (2022)

Tumour necrosis factor gene polymorphism: a predictive factor for the development of post-transplant lymphoproliferative disease
por: McAulay, K A, et al.
Publicado: (2009)

Screening and Identification of Lassa Virus Entry Inhibitors from a Fragment-Based Drug Discovery Library
por: Hou, Yuxia, et al.
Publicado: (2022)

Embracing the Diversity of Halogen Bonding Motifs in Fragment-Based Drug Discovery—Construction of a Diversity-Optimized Halogen-Enriched Fragment Library
por: Heidrich, Johannes, et al.
Publicado: (2019)

NMR quality control of fragment libraries for screening
por: Sreeramulu, Sridhar, et al.
Publicado: (2020)

The EFFECT trial: evaluating exacerbations, biomarkers, and safety outcomes with two dose levels of fluticasone propionate/formoterol in COPD
por: Papi, Alberto, et al.
Publicado: (2015)

Eating disorders, bipolar disorders and other mood disorders: complex and under-researched relationships
por: McAulay, Claire, et al.
Publicado: (2019)

Fragment-based drug discovery of small molecule ligands for the human chemokine CCL28
por: Zhou, Angela L., et al.
Publicado: (2023)

A case of concomitant clinical and histopathologic features of lymphocytic thrombophilic arteritis and livedoid vasculopathy
por: Gan, Christian, et al.
Publicado: (2023)

The impact of a ventilation timing light on CPR Quality: A randomized crossover study
por: Jones, Ben, et al.
Publicado: (2023)

Fragments and hot spots in drug discovery
por: Vajda, Sandor, et al.
Publicado: (2015)

Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
por: Bugni, Tim S., et al.
Publicado: (2008)

MolDiscovery: learning mass spectrometry fragmentation of small molecules
por: Cao, Liu, et al.
Publicado: (2021)

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53
por: Wilcken, Rainer, et al.
Publicado: (2012)

Targeting the ubiquitin system by fragment-based drug discovery
por: Kennedy, Cassandra, et al.
Publicado: (2022)

Fragment-Based Lead Discovery Strategies in Antimicrobial Drug Discovery
por: Konaklieva, Monika I., et al.
Publicado: (2023)

Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (Cyrene(TM))
por: Dekker, Tom, et al.
Publicado: (2023)

Fragment approaches in structure-based drug discovery
por: Hubbard, Roderick E.
Publicado: (2008)

Is it time for biocatalysis in fragment-based drug discovery?
por: Ramsden, Jeremy I., et al.
Publicado: (2020)

Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening
por: Wu, Chun-Yi, et al.
Publicado: (2016)

Fragment-Based Library Generation for the Discovery of a Peptidomimetic p53-Mdm4 Inhibitor
por: Boltjes, André, et al.
Publicado: (2014)

Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors
por: Keeley, A., et al.
Publicado: (2018)

Discovery of Fragment Molecules That Bind the Human Peroxiredoxin 5 Active Site
por: Barelier, Sarah, et al.
Publicado: (2010)

A diverse global fungal library for drug discovery
por: Niu, Guodong, et al.
Publicado: (2020)

MBC and ECBL libraries: outstanding tools for drug discovery
por: Ginex, Tiziana, et al.
Publicado: (2023)

Parsing Molecules for Drug Discovery
por: Walker, Allison S., et al.
Publicado: (2020)

Second-Generation DNA-Templated Macrocycle Libraries for the Discovery of Bioactive Small Molecules
por: Usanov, Dmitry L., et al.
Publicado: (2018)

Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
por: Proj, Matic, et al.
Publicado: (2022)

Native Mass Spectrometry in Fragment-Based Drug Discovery
por: Pedro, Liliana, et al.
Publicado: (2016)

Application of Fragment-Based Drug Discovery to Versatile Targets
por: Li, Qingxin
Publicado: (2020)

Fragment-based drug discovery: opportunities for organic synthesis
por: St. Denis, Jeffrey D., et al.
Publicado: (2020)

Implications of Fragment-Based Drug Discovery in Tuberculosis and HIV
por: Mallakuntla, Mohan Krishna, et al.
Publicado: (2022)

ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery
por: Saei, Amir Ata, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6ast5s2ei1bol7v2vjmms1rj20