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Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR‐based screens

The concepts of synthetic lethality and viability have emerged as powerful approaches to identify vulnerabilities and resistances within the DNA damage response for the treatment of cancer. Historically, interactions between two genes have had a longstanding presence in genetics and have been identi...

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Detalles Bibliográficos
Autores principales: Wilson, Jordan, Loizou, Joanna I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627789/
https://www.ncbi.nlm.nih.gov/pubmed/35708734
http://dx.doi.org/10.1002/1878-0261.13272