Cargando…

Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR‐based screens

The concepts of synthetic lethality and viability have emerged as powerful approaches to identify vulnerabilities and resistances within the DNA damage response for the treatment of cancer. Historically, interactions between two genes have had a longstanding presence in genetics and have been identi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wilson, Jordan, Loizou, Joanna I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627789/ https://www.ncbi.nlm.nih.gov/pubmed/35708734 http://dx.doi.org/10.1002/1878-0261.13272

Ejemplares similares

Interplay between Cellular Metabolism and the DNA Damage Response in Cancer
por: Moretton, Amandine, et al.
Publicado: (2020)

Interplay of space radiation and microgravity in DNA damage and DNA damage response
por: Moreno-Villanueva, María, et al.
Publicado: (2017)

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy
por: Moretton, Amandine, et al.
Publicado: (2022)

Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells
por: Ferreira da Silva, Joana, et al.
Publicado: (2019)

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens
por: Timms, Richard T., et al.
Publicado: (2016)

ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress
por: Schmidt, Luisa, et al.
Publicado: (2014)

Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease
por: Prochazkova, Jana, et al.
Publicado: (2015)

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
por: Marceau, Caleb D., et al.
Publicado: (2016)

CRISPR screen identifies the role of RBBP8 in mediating unfolded protein response induced liver damage through regulating protein synthesis
por: Wang, Heting, et al.
Publicado: (2023)

A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage
por: Zou, Xueqing, et al.
Publicado: (2021)

CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies
por: Jiang, Long, et al.
Publicado: (2022)

A CRISPR response to pandemics?: Exploring the ethics of genetically engineering the human immune system
por: Germani, Federico, et al.
Publicado: (2021)

A Targeted and Tuneable DNA Damage Tool Using CRISPR/Cas9
por: Emmanouilidis, Ioannis, et al.
Publicado: (2021)

Genetic vulnerabilities upon inhibition of DNA damage response
por: Wang, Chao, et al.
Publicado: (2021)

Genetic Regulation of Dna2 Localization During the DNA Damage Response
por: Yimit, Askar, et al.
Publicado: (2015)

Yeast genetic interaction screens in the age of CRISPR/Cas
por: Adames, Neil R., et al.
Publicado: (2018)

Application of CRISPR genetic screens to investigate neurological diseases
por: So, Raphaella W. L., et al.
Publicado: (2019)

Targeting DNA damage response in cancer therapy
por: Hosoya, Noriko, et al.
Publicado: (2014)

Targeting the DNA damage response for cancer therapy
por: Curtin, Nicola J.
Publicado: (2023)

Targeting the DNA Damage Response for Cancer Therapy
por: Wang, Ruoxi, et al.
Publicado: (2023)

Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing
por: Meyenberg, Mathilde, et al.
Publicado: (2021)

Discovery of novel DNA‐damaging agents through phenotypic screening for DNA double‐strand break
por: Zhang, Doudou, et al.
Publicado: (2022)

A DNA-Free Editing Platform for Genetic Screens in Soybean via CRISPR/Cas9 Ribonucleoprotein Delivery
por: Subburaj, Saminathan, et al.
Publicado: (2022)

Orthologous CRISPR-Cas9 enzymes for Combinatorial Genetic Screens
por: Najm, Fadi J, et al.
Publicado: (2017)

Minimized combinatorial CRISPR screens identify genetic interactions in autophagy
por: Diehl, Valentina, et al.
Publicado: (2021)

Drug Discovery Targeting Post-Translational Modifications in Response to DNA Damages Induced by Space Radiation
por: Xie, Dafei, et al.
Publicado: (2023)

Harnessing the Nucleolar DNA Damage Response in Cancer Therapy
por: Xuan, Jiachen, et al.
Publicado: (2021)

DNA Damage Baseline Predicts Resilience to Space Radiation and Radiotherapy
por: Pariset, Eloise, et al.
Publicado: (2020)

Applications and explorations of CRISPR/Cas9 in CAR T-cell therapy
por: Li, Chenggong, et al.
Publicado: (2020)

CRISPR Screens in Synthetic Lethality and Combinatorial Therapies for Cancer
por: Castells-Roca, Laia, et al.
Publicado: (2021)

A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability
por: Moretton, Amandine, et al.
Publicado: (2023)

Herpesviruses control the DNA damage response through TIP60
por: Li, Renfeng, et al.
Publicado: (2012)

Impact of DNA Damage Response—Targeted Therapies on the Immune Response to Tumours
por: Lutfi, Nura, et al.
Publicado: (2021)

Combination therapy for HCC: from CRISPR screening to the design of clinical therapies
por: Wang, Yunguang, et al.
Publicado: (2021)

Application of combined CRISPR screening for genetic and chemical-genetic interaction profiling in Mycobacterium tuberculosis
por: Yan, Mei-Yi, et al.
Publicado: (2022)

A CRISPR-based assay for the study of eukaryotic DNA repair onboard the International Space Station
por: Stahl-Rommel, Sarah, et al.
Publicado: (2021)

DNA Damage Response
por: Oksenych, Valentyn, et al.
Publicado: (2021)

DNA2—An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?
por: Pawłowska, Elzbieta, et al.
Publicado: (2017)

The Therapeutic Synergy of Selinexor and Venetoclax in Mantle Cell Lymphoma Through Induction of DNA Damage and Perturbation of the DNA Damage Response
por: Yuan, Sheng, et al.
Publicado: (2023)

Exploring Genetic Markers: Mitochondrial DNA and Genomic Screening for Biodiversity and Production Traits in Donkeys
por: Huang, Bingjian, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qhjg3frk8d1ob19k9erivvrec7