ODP443 Targeting NAD+ availability modulates 11β- Hydroxysteroid dehydrogenase 1 activity in mouse and human cell lines and primary cells

Four nicotinamide adenine dinucleotide coenzymes – NAD+, NADH, NADP+, and NADPH – are the central catalysts of metabolism. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is NADPH-dependent reductase that catalyses the reduction of the inactive glucocorticoid cortisone) to active corti...

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Detalles Bibliográficos
Autores principales: Kabli, Ali, Elhassan, Yasir, Heising, Silke, Heaselgrave, Samuel, Hardy, Rowan, Hodson, David, Morgan, Stuart, Lavery, Gareth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Steroid Hormones and Receptors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627921/
http://dx.doi.org/10.1210/jendso/bvac150.1485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627921/
http://dx.doi.org/10.1210/jendso/bvac150.1485

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