Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells

BACKGROUND: High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME). Depletion of L-Arg has detrimental consequences for T cells and leads to T...

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Detalles Bibliográficos
Autores principales: Weis-Banke, Stine Emilie, Lisle, Thomas Landkildehus, Perez-Penco, Maria, Schina, Aimilia, Hübbe, Mie Linder, Siersbæk, Majken, Holmström, Morten Orebo, Jørgensen, Mia Aaboe, Marie Svane, Inge, Met, Özcan, Ødum, Niels, Madsen, Daniel Hargbøl, Donia, Marco, Grøntved, Lars, Andersen, Mads Hald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628693/
https://www.ncbi.nlm.nih.gov/pubmed/36316062
http://dx.doi.org/10.1136/jitc-2022-005326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628693/
https://www.ncbi.nlm.nih.gov/pubmed/36316062
http://dx.doi.org/10.1136/jitc-2022-005326

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