Cargando…

Nickel-catalyzed enantioselective α-heteroarylation of ketones via C–F bond activation to construct all-carbon quaternary stereocenters

Nickel-catalyzed asymmetric α-heteroarylation of ketones with fluorinated heteroarenes is reported via C–F bond activation. A series of ketones and 2-fluoropyridine derivatives with different functional groups proceed well to provide the corresponding products containing all-carbon quaternary stereo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Xiaodong, Liu, Kexin, Yang, Limin, Xie, Chengyi, Li, Mingliang, Wang, Jun (Joelle)
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629005/ https://www.ncbi.nlm.nih.gov/pubmed/36382277 http://dx.doi.org/10.1039/d2sc03409c

Ejemplares similares

Enantioselective Construction of Remote Quaternary Stereocenters
por: Mei, Tian-Sheng, et al.
Publicado: (2014)

Catalytic enantioselective construction of vicinal quaternary carbon stereocenters
por: Zhou, Feng, et al.
Publicado: (2020)

Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides
por: Wang, Jiawen, et al.
Publicado: (2021)

Stereospecific Construction of Quaternary Carbon Stereocenters from Quaternary Carbon Stereocenters
por: Patel, Kaushalendra, et al.
Publicado: (2022)

Enantioselective Synthesis of Aza-Flavanones with an All-Carbon Quaternary Stereocenter via NHC-Catalyzed Intramolecular Annulation
por: Barańska, Izabela, et al.
Publicado: (2023)

Enantioselective construction of triaryl-substituted all-carbon quaternary stereocenters via organocatalytic arylation of oxindoles with azonaphthalenes
por: Chen, Pengquan, et al.
Publicado: (2023)

Catalytic Enantioselective Entry to Triflones Featuring a Quaternary Stereocenter
por: Franco, Francesca, et al.
Publicado: (2022)

Biocatalytic Conversion of Cyclic Ketones Bearing α‐Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium‐Sized Carbocycles
por: Morrill, Charlotte, et al.
Publicado: (2018)

Construction of polycyclic structures with vicinal all-carbon quaternary stereocenters via an enantioselective photoenolization/Diels–Alder reaction
por: Hou, Min, et al.
Publicado: (2021)

Enantioselective rhodium-catalyzed addition of arylboronic acids to N-heteroaryl ketones: synthesis of α-hydroxy acids
por: Zhu, Jinbin, et al.
Publicado: (2023)

Stereoinvertive Nucleophilic Substitution at Quaternary Carbon Stereocenters of Cyclopropyl Ketones and Ethers
por: Chen, Xu, et al.
Publicado: (2022)

Direct catalytic enantioselective amination of ketones for the formation of tri- and tetrasubstituted stereocenters
por: Trost, B. M., et al.
Publicado: (2018)

Highly Enantioselective Iridium(I)‐Catalyzed Hydrocarbonation of Alkenes: A Versatile Approach to Heterocyclic Systems Bearing Quaternary Stereocenters
por: Arribas, Andrés, et al.
Publicado: (2021)

Palladium-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Lactams: Enantioselective Construction of All-Carbon Quaternary Stereocenters in Saturated Nitrogen-Containing Heterocycles
por: Zhang, Tianyi, et al.
Publicado: (2023)

Doubly stereoconvergent construction of vicinal all-carbon quaternary and tertiary stereocenters by Cu/Mg-catalyzed propargylic substitution
por: Pu, Xiang, et al.
Publicado: (2022)

Enantioselective [3+2]-cycloaddition of 2,3-disubstituted cyclobutenones: vicinal quaternary stereocenters construction and skeletal functionalization
por: Lu, Licheng, et al.
Publicado: (2023)

Enantioselective Nickel‐Catalyzed anti‐Arylmetallative Cyclizations onto Acyclic Ketones
por: Green, Harley, et al.
Publicado: (2021)

Enantioselective Construction of Tertiary Fluoride Stereocenters by Organocatalytic Fluorocyclization
por: Wang, Qiang, et al.
Publicado: (2020)

Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine
por: Zhang, Qing, et al.
Publicado: (2019)

Cross-dehydrogenative coupling enables enantioselective access to CF(3)-substituted all-carbon quaternary stereocenters
por: Pan, Xiaoguang, et al.
Publicado: (2020)

Organocatalytic asymmetric formal oxidative coupling for the construction of all-aryl quaternary stereocenters
por: Li, Zhiyang, et al.
Publicado: (2021)

Coinage Metal-Catalyzed Asymmetric Reactions of ortho-Alkynylaryl and Heteroaryl Aldehydes and Ketones
por: Melot, Romain, et al.
Publicado: (2022)

Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones
por: Zheng, Haifeng, et al.
Publicado: (2018)

Palladium-catalyzed enantioselective Heck alkenylation of trisubstituted allylic alkenols: a redox-relay strategy to construct vicinal stereocenters
por: Zhang, Chun, et al.
Publicado: (2017)

Highly stereoselective nickel-catalyzed difluoroalkylation of aryl ketones to tetrasubstituted monofluoroalkenes and quaternary alkyl difluorides
por: Li, Chao, et al.
Publicado: (2019)

Enantioselective nickel-catalyzed arylative and alkenylative intramolecular 1,2-allylations of tethered allene–ketones
por: Di Sanza, Riccardo, et al.
Publicado: (2020)

Chromium(II)-catalyzed enantioselective arylation of ketones
por: Wang, Gang, et al.
Publicado: (2016)

Enantioselective Construction of Quaternary N-Heterocycles by Palladium-Catalyzed Decarboxylative Allylic Alkylation of Lactams
por: Behenna, Douglas C., et al.
Publicado: (2011)

Nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the Ni(NIXANTPHOS)-based catalyst
por: Cao, Xinyu, et al.
Publicado: (2016)

Enantioselective [2 + 2] cycloaddition of N-allenamides with cyclic N-sulfonylketimines: access to polysubstituted azetidines bearing quaternary stereocenters
por: Liu, Ren-Rong, et al.
Publicado: (2017)

Enantioselective Synthesis of Acyclic Orthogonally Functionalized Compounds Bearing a Quaternary Stereocenter Using Chiral Ammonium Salt Catalysis
por: Röser, Katharina, et al.
Publicado: (2021)

Stereoselective Construction of Tertiary Homoallyl Alcohols and Ethers by Nucleophilic Substitution at Quaternary Carbon Stereocenters
por: Chen, Xu, et al.
Publicado: (2022)

Construction of 4-hydroxycoumarin derivatives with adjacent quaternary and tertiary stereocenters via ternary catalysis
por: Zhang, Mengchu, et al.
Publicado: (2023)

Boron-Catalyzed, Diastereo- and Enantioselective Allylation of Ketones with Allenes
por: Nicholson, Kieran, et al.
Publicado: (2022)

Iridium-Catalyzed Enantioselective Alkene Hydroalkylation via a Heteroaryl-Directed Enolization–Decarboxylation Sequence
por: Jing, Changcheng, et al.
Publicado: (2023)

Nickel-catalyzed enantioselective arylation of pyridine
por: Lutz, J. Patrick, et al.
Publicado: (2016)

Enzymatic Enantioselective Decarboxylative Protonation of Heteroaryl Malonates
por: Lewin, Ross, et al.
Publicado: (2015)

Asymmetric Construction of All-Carbon Quaternary Stereocenters by Chiral-Auxiliary-Mediated Claisen Rearrangement and Total Synthesis of (+)-Bakuchiol
por: Takao, Ken-ichi, et al.
Publicado: (2012)

Enantioselective Generation of Adjacent Stereocenters in a Copper‐Catalyzed Three‐Component Coupling of Imines, Allenes, and Diboranes
por: Yeung, Kay, et al.
Publicado: (2016)

Catalytic enantioselective synthesis of fluoromethylated stereocenters by asymmetric hydrogenation
por: Yang, Jianping, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_18lkag6cgjhfp4gqqid5i3aruv