Highly effective identification of drug targets at the proteome level by pH-dependent protein precipitation

Fully understanding the target spaces of drugs is essential for investigating the mechanism of drug action and side effects, as well as for drug discovery and repurposing. In this study, we present an energetics-based approach, termed pH-dependent protein precipitation (pHDPP), to probe the ligand-i...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaolei, Wang, Keyun, Wu, Sijin, Ruan, Chengfei, Li, Kejia, Wang, Yan, Zhu, He, Liu, Xiaoyan, Liu, Zhen, Li, Guohui, Hu, Lianghai, Ye, Mingliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629037/
https://www.ncbi.nlm.nih.gov/pubmed/36382280
http://dx.doi.org/10.1039/d2sc03326g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629037/
https://www.ncbi.nlm.nih.gov/pubmed/36382280
http://dx.doi.org/10.1039/d2sc03326g

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