Cargando…

PA-X protein of H1N1 subtype influenza virus disables the nasal mucosal dendritic cells for strengthening virulence

PA-X protein arises from a ribosomal frameshift in the PA of influenza A virus (IAV). However, the immune regulatory effect of the PA-X protein of H1N1 viruses on the nasal mucosal system remains unclear. Here, a PA-X deficient H1N1 rPR8 viral strain (rPR8-△PAX) was generated and its pathogenicity w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Tao, Chen, Yulian, Huangfu, Dandan, Yin, Yinyan, Miao, Xinyu, Yin, Yuncong, Chen, Sujuan, Peng, Daxin, Liu, Xiufan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629126/ https://www.ncbi.nlm.nih.gov/pubmed/36271710 http://dx.doi.org/10.1080/21505594.2022.2139474

Ejemplares similares

PA-X protein of H9N2 subtype avian influenza virus suppresses the innate immunity of chicken bone marrow-derived dendritic cells
por: Qin, Tao, et al.
Publicado: (2022)

Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune‐Adjuvant
por: Qin, Tao, et al.
Publicado: (2020)

Bidirectionally Regulating Viral and Cellular Ferroptosis with Metastable Iron Sulfide Against Influenza Virus
por: Miao, Xinyu, et al.
Publicado: (2023)

Riboflavin as a Mucosal Adjuvant for Nasal Influenza Vaccine
por: Yin, Yinyan, et al.
Publicado: (2021)

Generation of an avian influenza DIVA vaccine with a H3-peptide replacement located at HA2 against both highly and low pathogenic H7N9 virus
por: Li, Gang, et al.
Publicado: (2022)

Emerging of H5N6 Subtype Influenza Virus with 129-Glycosylation Site on Hemagglutinin in Poultry in China Acquires Immune Pressure Adaption
por: Xu, Nuo, et al.
Publicado: (2022)

Catalytic inactivation of influenza virus by iron oxide nanozyme
por: Qin, Tao, et al.
Publicado: (2019)

Glycosylation at 11Asn on hemagglutinin of H5N1 influenza virus contributes to its biological characteristics
por: Yin, Yuncong, et al.
Publicado: (2017)

Characterization of an H7N9 Influenza Virus Isolated from Camels in Inner Mongolia, China
por: Yin, Yuncong, et al.
Publicado: (2023)

Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in mice
por: Wang, Xiao, et al.
Publicado: (2017)

Truncation or Deglycosylation of the Neuraminidase Stalk Enhances the Pathogenicity of the H5N1 Subtype Avian Influenza Virus in Mallard Ducks
por: Chen, Sujuan, et al.
Publicado: (2020)

The synergistic effect of residues 32T and 550L in the PA protein of H5 subtype avian influenza virus contributes to viral pathogenicity in mice
por: Yang, Hui, et al.
Publicado: (2023)

Generation and Comprehensive Analysis of Host Cell Interactome of the PA Protein of the Highly Pathogenic H5N1 Avian Influenza Virus in Mammalian Cells
por: Gao, Zhao, et al.
Publicado: (2017)

Efficacy of Live-Attenuated H9N2 Influenza Vaccine Candidates Containing NS1 Truncations against H9N2 Avian Influenza Viruses
por: Chen, Sujuan, et al.
Publicado: (2017)

Development of a multiplex probe combination-based one-step real-time reverse transcription-PCR for NA subtype typing of avian influenza virus
por: Sun, Zhihao, et al.
Publicado: (2017)

Effects of virulent and attenuated transmissible gastroenteritis virus on the ability of porcine dendritic cells to sample and present antigen
por: Zhao, Shanshan, et al.
Publicado: (2014)

Roles of the spiA gene from Salmonella enteritidis in biofilm formation and virulence
por: Dong, Hongyan, et al.
Publicado: (2011)

A 20-Amino-Acid Deletion in the Neuraminidase Stalk and a Five-Amino-Acid Deletion in the NS1 Protein Both Contribute to the Pathogenicity of H5N1 Avian Influenza Viruses in Mallard Ducks
por: Li, Yanfang, et al.
Publicado: (2014)

The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses
por: Gao, Huijie, et al.
Publicado: (2015)

H1N1 Influenza Virus-Infected Nasal Mucosal Epithelial Progenitor Cells Promote Dendritic Cell Recruitment and Maturation
por: Zhu, Fangyuan, et al.
Publicado: (2022)

The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1/STAT signalling
por: Yang, Hui, et al.
Publicado: (2022)

Identification of a universal antigen epitope of influenza A virus using peptide microarray
por: Wang, Qiuxia, et al.
Publicado: (2021)

PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice
por: Hu, Jiao, et al.
Publicado: (2016)

Intercellular adhesion molecule-1 expression in activated eosinophils is associated with mucosal remodeling in nasal polyps
por: XIN, JINGWEI, et al.
Publicado: (2015)

Melatonin Suppresses LPS-Induced Oxidative Stress in Dendritic Cells for Inflammatory Regulation via the Nrf2/HO-1 Axis
por: Qin, Tao, et al.
Publicado: (2022)

Genome Sequence of a Novel H10N9 Avian Influenza Virus Isolated from Chickens in a Live Poultry Market in Eastern China
por: Su, Chunhu, et al.
Publicado: (2013)

Development of a Colloidal Gold-Based Immunochromatographic Strip for Rapid Detection of H7N9 Influenza Viruses
por: Sun, Zhihao, et al.
Publicado: (2018)

Development of an Inactivated H7N9 Subtype Avian Influenza Serological DIVA Vaccine Using the Chimeric HA Epitope Approach
por: Sun, Zhihao, et al.
Publicado: (2021)

Mucosal dendritic cells shape mucosal immunity
por: Chang, Sun-Young, et al.
Publicado: (2014)

PA-X: a key regulator of influenza A virus pathogenicity and host immune responses
por: Hu, Jiao, et al.
Publicado: (2018)

The deletion of an extra six nucleotides in the 5′ -untranslated region of the nucleoprotein gene of Newcastle disease virus NA-1 decreases virulence
por: Liu, Jiaxu, et al.
Publicado: (2014)

Bursopentin (BP5) Protects Dendritic Cells from Lipopolysaccharide-Induced Oxidative Stress for Immunosuppression
por: Qin, Tao, et al.
Publicado: (2015)

G1-like M and PB2 genes are preferentially incorporated into H7N9 progeny virions during genetic reassortment
por: Li, Xiuli, et al.
Publicado: (2021)

Phenotype and function of nasal dendritic cells
por: Lee, Haekyung, et al.
Publicado: (2015)

LEP1 cryoplants (PA4/PA8)
por: Barth, K, et al.
Publicado: (2000)

Intranasal administration of regulatory dendritic cells is useful for the induction of nasal mucosal tolerance in a mice model of allergic rhinitis
por: Suzuki, Motohiko, et al.
Publicado: (2020)

Deep sequencing of the mouse lung transcriptome reveals distinct long non-coding RNAs expression associated with the high virulence of H5N1 avian influenza virus in mice
por: Hu, Jiao, et al.
Publicado: (2018)

The emergence of new antigen branches of H9N2 avian influenza virus in China due to antigenic drift on hemagglutinin through antibody escape at immunodominant sites
por: Zhang, Nan, et al.
Publicado: (2023)

The Development of Nasal Polyp Disease Involves Early Nasal Mucosal Inflammation and Remodelling
por: Meng, Juan, et al.
Publicado: (2013)

Deletion of the PA4427-PA4431 Operon of Pseudomonas aeruginosa PAO1 Increased Antibiotics Resistance and Reduced Virulence and Pathogenicity by Affecting Quorum Sensing and Iron Uptake
por: Shen, Lixin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eordt08ropjsaj0lenbuj9ifdb