OR16-1 How Strong and Sustained Activation of the Estrogen Receptor-mediated Anticipatory Unfolded Protein Response Kills Breast and Ovarian Cancer Cells

In orthotopic xenografts and a PDX, our anticancer drug ErSO eradicates primary and metastatic therapy-resistant estrogen receptor alpha (ERα) positive breast cancer, and induces near-complete regression of ovarian cancer. The mechanism by which ErSO induces necrosis and kills ER positive cancer cel...

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Detalles Bibliográficos
Autores principales: Boudreau, Matthew, Duraki, Darjan, Hergenrother, Paul, Kim, Ji Eun, Livezey, Mara, Nelson, Erik, Park, Ben H, Shapiro, David, Yang, Rachel, Ghosh, Santanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Tumor Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629161/
http://dx.doi.org/10.1210/jendso/bvac150.1820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629161/
http://dx.doi.org/10.1210/jendso/bvac150.1820

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